Inhibitory effects of egg yolk soluble protein on bone resorption.
نویسندگان
چکیده
We determined the effects of yolk water-soluble protein (YSP) on bone resorption. YSP potently suppressed osteoclastogenesis from bone marrow-derived precursor cells driven by tumor necrosis factor-alpha (TNF-alpha). YSP (200 microg/ml) abolished the formation of tartarate-resistant acid phosphatase (TRAP)-positive osteoclasts. Furthermore, TNF-alpha induced TRAP activity was greatly inhibited by YSP (100 microg/ml) treatment. Our results suggest that YSP has therapeutic potential for bone-erosive diseases.
منابع مشابه
Effects of food enriched with egg yolk hydrolysate (bone peptide) on bone metabolism in orchidectomized dogs
We examined the effects of chicken egg hydrolysate (also known as "bone peptide" or BP) on bone metabolism in 5- to 8-month-old orchidectomized dogs. The bone formation marker serum bone alkaline phosphatase (BAP) and the bone resorption marker urine deoxypyridinoline (DPD) were used as indicators to measure changes in bone metabolism. The following results were observed that Serum BAP was high...
متن کاملAntiosteoporotic effect of orally administered yolk-derived peptides on bone mass in women
The main objective of this study was to verify the effect of oral intake of a yolk-derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water-soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6-month, randomized, double-blind clinical trial. Bo...
متن کاملModification of egg yolk fatty acids profile by using different oil sources
The study was conducted to evaluate the effects of different dietary oil sources supplementation on laying hens’ performance and fatty acids profile of egg yolks. Seventy-two 23-week-old laying hens (Tetra-SL) divided into six experimental diets (four replicates and three birds per replication) in a completely randomized design for nine weeks. Experimental diets were included: 1) control (no oi...
متن کاملEffects of Pigments Extracted from the Marigold Flower on Egg Quality and Oxidative Stability of the Egg Yolk Lipids in Laying Hens
This research aimed to compare the effects of pigments extracted from dried petal meal of marigold flower and synthetic pigments on productive performance of laying hens, egg quality and antioxidant properties of the egg. A total of 64 laying hens, aged 75 weeks, were distributed in a completely randomized design in 4 treatments and 4 replications containing 4 hens per cages. Experimental group...
متن کاملEgg yolk oil as a source of bioactive compounds for infant nutrition
Egg yolk oil is a natural source of bioactive compounds such as DHA, fat–soluble vitamins, lutein, phospholipids and cholesterol. These important compounds are also found in breast milk: DHA for infant brain development, lutein for eye health, vitamins A and E to support developing cells. Egg yolk oil naturally contains vitamin D which is required for a normal bone development. Fatty acid profi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Bioscience, biotechnology, and biochemistry
دوره 72 7 شماره
صفحات -
تاریخ انتشار 2008